Spravato® (Esketamine) Treatment Gilbert
At Gilbert Chandler Psychiatrists, Spravato® is provided as part of comprehensive psychiatric care for adults whose depression has not improved with standard treatments. Care is led by Dr. Mark Feinstein, DO, Psychiatrist, and Brittany Khoury, PMHNP-BC, who bring extensive clinical experience and a patient-centered approach to treatment.
Every patient begins with a thorough psychiatric evaluation. Dr. Feinstein and Brittany work together to review treatment history, current symptoms, and individual goals before recommending Spravato®. Treatment decisions are thoughtful and never rushed.
Spravato® sessions are conducted in a safe, medically supervised clinic setting with close monitoring and ongoing follow-up. This service is designed for patients who feel stuck despite trying multiple options and need a carefully guided next step toward meaningful improvement.
What Is Spravato® (Esketamine)?
Spravato® is a prescription nasal spray containing esketamine. It is FDA-approved for specific depressive conditions and is typically considered when traditional antidepressants haven’t provided enough improvement.
Unlike many first-line antidepressants that primarily target serotonin, Spravato® works through a different pathway in the brain (commonly described as the glutamate system). Because of this, some patients may feel symptom relief faster than with traditional medication timelines—though response varies person to person.
Why Spravato® Is Different From Traditional Antidepressants
Spravato® works through a different pathway in the brain than most antidepressants, which is why it may help when other treatments haven’t. Key differences include:
- Targets the brain’s glutamate system, not just serotonin
- May provide faster symptom relief for some patients
- Administered in a controlled medical setting
- Used as part of a structured treatment plan, not daily at-home dosing
How Spravato® Treatment Works
Spravato® is administered only in-clinic as part of a supervised treatment program. Each visit includes:
- Guided self-administration of the nasal spray
- Continuous medical monitoring for at least two hours
- Observation for side effects and response
- Discharge once stable, with post-visit instructions
What Conditions Is Spravato® Used to Treat?
Spravato® is most commonly used for:
- Treatment-Resistant Depression (TRD): When two or more antidepressants have not provided adequate relief
- Severe Major Depressive Disorder: Persistent, function-limiting symptoms despite ongoing treatment
- Depression With Acute Suicidal Thoughts: In carefully evaluated cases and under close medical supervision
Spravato® vs Other Advanced Depression Treatments
Spravato® is often considered alongside options such as TMS or IV ketamine. Spravato® may be preferred when:
- Insurance coverage is important
- A standardized, FDA-approved protocol is desired
- In-clinic monitoring is appropriatek
Your provider will help compare options and guide the decision.
Benefits of Spravato® Treatment
Patients often consider Spravato® because it may offer:
- Relief when other medications haven’t worked
- A faster onset of symptom improvement for some individuals
- Reduced intensity of depressive or ruminative thought patterns
- Improved ability to engage in therapy and daily activities
- A structured, closely monitored treatment experience
Individual results vary, and not every patient is a candidate.
Typical Spravato® Treatment Schedule
Treatment usually follows a phased approach:
- Induction phase: Twice weekly for the first few weeks
- Stabilization phase: Weekly treatments
- Maintenance phase: Every one to two weeks, if beneficial
Your provider will adjust frequency based on response and tolerance.
Book An Appointment
We provide complimentary consultation. One of our experienced doctors will discuss your concerns and provide guidance.
Call Us on (480) 256-9322 or fill the form below to receive a call back.
Frequently Asked Questions (FAQs)
What should I expect from a Spravato® appointment?
A guided nasal administration, followed by at least two hours of monitoring before discharge
How quickly does Spravato® work?
Some people notice changes sooner than typical antidepressant timelines, but results vary. The goal is steady, measurable improvement with structured follow-up.
How long do the effects last?
Many patients require a maintenance plan if Spravato® is helpful. Your provider will tailor frequency based on your response and stability.
Can Spravato® help with anxiety or OCD?
Spravato® is primarily used for depressive conditions, but many people with depression also experience anxiety symptoms. Your provider will clarify expected benefits based on your diagnosis.
Do I have to do therapy too?
Not always—but combining biological treatments with therapy is often recommended. Brittany emphasizes that faster relief can help people engage more in therapy and long-term changes
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